Effect of adrenaline and nor adrenaline on isolated rat ureter preparations.

The effect of adrenaline and nor-adrenaline on the spontaneously contracting and quiescent isolated proximal and central pieces of ureters obtained from female (virgin) albino rats of the Sprague Dawley strain were studicd, Adrenaline and nor-adrenaline produced a stimulant effect on the rate and amplitude of the proximal pieces of spontaneously contracting preparations. Both these drugs induced persistaltic activity in similar quiescent preparations. Adrenaline also produced a stimulant effect on the sport aneously contracting preparations of the central portions of the ureters. In view of these findings it is. suggested that as far as the responses to adrenaline and nor-adrenaline are concerned the proximal and the central portions of the isolated rat ureter preparations behave as if they possess a preponderance of alpha (excitatory) adrenergic receptors. (JPMA 33: 223, 1983).